The distribution of adhesive mechanisms

نویسندگان

  • S. Montefort
  • Baker
  • W. R. Roche
  • S. T. Holgate
چکیده

The distribulion of adhesive mechanisms in the normal bronchial epithelium. S. Montefort, J. Baker, W.R. Roche, S.T. Holgate. ©ERS Journals Lld 1993. Depts of *Immunopbarmacology and ••Pathology, University of Southampton, Southampton, UK. ABSTRACT: The integrity of the bronchial epithelium is dependent on various adhesion mechanisms that sen-e to bold the composite structure or the epithelium together and anchor it to the underlying basement membrane. Using immunobistochemic;try we wanted to map out a number of these junctional and oon-jundiooaJ adhesion mechanisms in the normal bUD1lUl bronchial epitbelium. Correspondence: S. Montef011 Dept of lmmWJOphannacology Medicine 1, Level D, Centre Block Southampton General Hospital Tremona Road The ~!-associated integrin subunit a2 was immunolocalized to all or the epithelial inten:eUular spaces, whilst a6 and JW were strongly evident at the basal cell layer basement membrane junction. The al and aS integrin subunits were not detected anywhere in the epithelium. Southampton S09 4XY UK

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تاریخ انتشار 2012